Association of a FAM13A variant with interstitial lung disease in Japanese rheumatoid arthritis
Authors' conclusion
This study is the first to document an association of rs2609255 with ILD in Japanese patients with RA, implicating it in the pathogenesis of UIP
Study context
- Population
- Japanese patients with rheumatoid arthritis (RA)
- Participants
- 208 vs 420
- Comparison
- RA with interstitial lung disease (ILD) vs RA without chronic lung disease
- RA WITH ILDn = 208
- RA WITHOUT CHRONIC LUNG DISEASEn = 420reference
- Outcome
- Association of FAM13A rs2609255 (G/T) with ILD (usual interstitial pneumonia (UIP)) in RA
Methodological detailsTaqMan genotyping
- TaqMan genotyping
Main finding
As reported in the abstract
UIP in RA, rs2609255
RA WITH ILD vs RA WITHOUT CHRONIC LUNG DISEASEOdds ratio (95% CI)P value
Allele model; Pc=0.0276
1.53(1.12–2.11)
P = 0.0092Recessive model for the G allele; Pc=0.0009
2.63(1.59–4.32)
P = 0.0003Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| UIP in male patients with RA (subgroup), rs2609255Recessive model | 3.65 (1.52–8.73) | P = 0.0043 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Association of a FAM13A variant with interstitial lung disease in Japanese rheumatoid arthritis. RMD Open. Published 30 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →