Association of rare single-nucleotide variant MUC5B rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis
Authors' conclusion
MUC5B rs35705950 is associated with, and might be involved in the pathogenesis of ILD, especially UIP, in Japanese RA.
Study context
- Population
- Japanese RA patients
- Comparison
- Carriers of candidate single-nucleotide variant (SNV) alleles vs non-carriers, for interstitial lung disease (ILD) in RA
- Outcome
- Association of candidate SNVs, including MUC5B rs35705950, with ILD in RA
Methodological detailscandidate SNV genotyping, allele model, haplotype analyses
- Candidate SNV genotyping
- Allele model
- Haplotype analyses
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
MUC5B rs35705950 (UIP)
10.66(2.05–55.37)
P = 0.0039, Pc = 0.0156MUC5B rs35705950 (ILD)
7.33(1.52–35.44)
P = 0.0071, Pc = 0.0284Further findings
Association of MUC2 rs7934606 with usual interstitial pneumonia (UIP) and ILD in RA
| OR (95% CI) | P value | ||
|---|---|---|---|
| MUC2 rs7934606 (UIP) | 29.55 (1.52–574.57) | P = 0.0072, Pc = 0.0288 | |
| MUC2 rs7934606 (ILD) | 22.95 (1.27–416.13) | P = 0.0037, Pc = 0.0148 | |
| 0.050.21520Odds ratio (log scale) |
MAD1L1 rs12699415 and PPFIBP2 rs6578890 with UIP, nonspecific interstitial pneumonia or ILD
- No significant association
Original publication
Association of rare single-nucleotide variant MUC5B rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis. Rheumatology (Oxford). Published 7 August 2024. doi:10.
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