Lupus & antiphospholipid syndrome
Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study
Authors' conclusion
SLE-related vasculitis seems very rare and other causes of vasculitis should be ruled out before considering this diagnosis. Moreover, in more than half of patients, CV was not associated with another sign of active SLE.
Study context
- Population
- SLE patients with biopsy-proven cutaneous vasculitis (CV), pathology departments of three university hospitals and a national call for cases35 (90%) female
- Participants
- 39 patients
- Outcome
- Clinical and pathological features of biopsy-proven CV associated with SLE: diagnosis classification and impact on overall SLE activity
- Follow-up
- At the time of CV diagnosis
Methodological detailsmulticentre, SLE defined by 1997 revised ACR and/or 2019 ACR/EULAR criteria; CV confirmed histologically and classified by the dermatological addendum of the Chapel Hill classification; SLE activity and flare severity assessed independently of vasculitis items with SELENA-SLEDAI and SELENA-SLEDAI Flare Index
- Multicentre
- SLE defined by 1997 revised ACR and/or 2019 ACR/EULAR criteria; CV confirmed histologically and classified by the dermatological addendum of the Chapel Hill classification; SLE activity and flare severity assessed independently of vasculitis items with SELENA-SLEDAI and SELENA-SLEDAI Flare Index
Main finding
As reported in the abstract
- Palpable purpura
- n = 21; 54%
- Urticarial lesions
- n = 18; 46%
- Lower limbs most common location
- n = 33; 85%
- Extracutaneous vasculitis
- Eleven (28%)
- CV classified as urticarial vasculitis
- n = 14, 36%
- CV classified as cryoglobulinaemia
- n = 13, 33%
- No cause other than SLE to explain CV
- 2 (5%)
- Inactive SLE
- Sixty-one percent
Observational data: associations, not effects.
Further findings
Prevalence of Sjögren's syndrome vs SLE patients without CV — SLE with CV vs French referral centre group (SLE without CV)
P < 0.0001
| Outcome | P value |
|---|---|
| Prevalence of Sjögren's syndrome vs SLE patients without CVSLE with CV vs Swiss SLE Cohort (SLE without CV) | P < 0.0001 |
Original publication
Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study. Rheumatology (Oxford). Published 3 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →