Lupus & antiphospholipid syndrome
Current smoking is related to severe damage in systemic lupus erythematosus patients
Main finding · Severe damage (SLICC-SDI ≥3), multiple regressionResult — go to the resultOdds ratio 1.82 95% CI 1.01–3.31Authors' conclusion
In our sample of patients, current smoking, older age, disease duration and cyclophosphamide were related to severe damage (SLICC-SDI ≥3).
Study context
- Population
- Consecutive systemic lupus erythematosus (SLE) patients (fulfilling ≥4, 1997 ACR criteria) from Argentina; 89% women89% women
- Participants
- 623 patients
- Exposure
- Current smokers vs non-smokers
- Outcome
- Severe organ damage, SLICC-SDI ≥3
Methodological detailsconsecutive patients, multiple regression analysis
- Consecutive patients
- Multiple regression analysis
Main finding
As reported in the abstract
Severe damage (SLICC-SDI ≥3), multiple regression
Odds ratio
1.82
95% CI 1.01–3.31
p 0.046
Smokersvs Non-smokers
OR 1.82 (95% CI 1.01–3.31); p 0.046
Observational data: associations, not effects.
Further findings
Current smokers among patients with SLICC-SDI ≥3 vs <3
p 0.081
Other factors related to SLICC-SDI ≥3 (multiple regression)
- Older age, OR (95% CI 1.00-1.05), p 0.034
- 1.04
- Disease duration, OR (95% CI 1.00-1.07), p 0.021
- 1.03
- Cyclophosphamide exposure, OR (95% CI 1.49-5.88), p 0.002
- 2.97
Prevalence of smoking and severe damage
- Current smokers
- 16 %
- Non-smokers
- 84%
- SLICC-SDI ≥3
- 17 %
- SLICC-SDI <3
- 83 percent
Original publication
Current smoking is related to severe damage in systemic lupus erythematosus patients. Lupus. Published 18 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →