Lupus & antiphospholipid syndrome
Critical peripheral ischemia: Higher prevalence in Indian systemic lupus erythematosus inception cohort for research (INSPIRE)
Authors' conclusion
CPI occurred in a higher proportion (2.9%) of SLE patients in the INSPIRE cohort as compared to earlier reports.
Study context
- Population
- Systemic Lupus erythematosus (SLE) patients enrolled into the Indian SLE inception cohort (INSPIRE)INSPIRE cohort
- Participants
- 2,503 patients
- Exposure
- SLE with critical peripheral ischemia vs all other SLE patients
- Critical peripheral ischemia (CPI)n = 75
- Outcome
- Prevalence of CPI (digital infarcts and gangrene) at enrolment
- Follow-up
- Enrolment
Methodological detailsanalysis of an inception cohort, web-based database, multivariable analysis
- Analysis of an inception cohort
- Web-based database
- Multivariable analysis
Main finding
As reported in the abstract
Prevalence of CPI
CPI
2.9%
75
Observational data: associations, not effects.
Further findings
Factors associated with CPI (multivariable analysis) · enrolment
| aOR (CI) | ||
|---|---|---|
| Pulmonary hypertension | 6.34 (1.99–20.2) | |
| Coexistent thrombosis | 27.8 (15.7–48.7) | |
| Triple aPL positivity | 5.36 (1.67–16.9) | |
| Anti-Scl-70 antibody | 5.59 (1.86–16.7) | |
| Class 3 or 4 LN | 0.37 (0.15–0.95) | |
| Anti-nucleosome antibodies | 0.47 (0.23–0.99) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Type of CPI
- Digital gangrene
- 55 (73.3%)
- Digital infarcts
- 21 (28%)
- Digital gangrene resulting in amputation distal to terminal phalanx
- 63.6%
SLEDAI and short-term mortality · up to 6 months
- Similar between cases and controls
Original publication
Critical peripheral ischemia: Higher prevalence in Indian systemic lupus erythematosus inception cohort for research (INSPIRE). Lupus. Published 26 June 2024. doi:10.
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