Lupus & antiphospholipid syndrome
The expression of Siglec-10 on naive B cells is involved in the pathology of systemic lupus erythematosus
Authors' conclusion
The results indicate that the upregulation of Siglec-10+/naive B cells may function as a feedback mechanism to regulate B cell hyperreactivity.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls
- Comparison
- Active SLE vs inactive SLE vs healthy controls
- Outcome
- Siglec-10 expression on B-cell subsets
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
- Elevated levels of Siglec-10 on naive B cells in active SLE
- Siglec-10+ B cells in active SLE showed elevated CD40 and CD21low levels vs healthy controls (HCs) and inactive SLE
- Siglec-10 on naive B cells positively correlated with proportion of CD21low double negative (DN) B cells and SLEDAI-2K score
Original publication
The expression of Siglec-10 on naive B cells is involved in the pathology of systemic lupus erythematosus. Clin Exp Rheumatol. Published 24 June 2024. doi:10.
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