COVID-19 infection and efficacy of vaccination in patients with rheumatic diseases during Omicron outbreak in South Korea: a prospective cohort study
Authors' conclusion
The risk of SARS-CoV-2 infection with the Omicron variant did not increase in patients with AIRDs. The third booster vaccination regimen decreased the infection rate in patients aged <70 years.
Study context
- Population
- Patients with and without autoimmune inflammatory rheumatic diseases during the Omicron wave, South Korea, January–October 2022analysed
- Participants
- 1,814 patients
- Exposure
- AIRD vs non-AIRD
- AIRDn = 1,535
- non-AIRDn = 279reference
- Outcome
- COVID-19 incidence during the study period, compared between AIRD and non-AIRD
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
COVID-19 infection
857 COVID-19 cases in 834 patients overall
46.0%
Observational data: associations, not effects.
Further findings
COVID-19 incidence with third booster vaccination (AIRD)
| aHR (95% CI) | ||
|---|---|---|
| Third booster vaccination | 0.85 (0.73–0.99) | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| COVID-19 incidence with third booster vaccination, aged <70 years (subgroup) | 0.81 (95% CI 0.69–0.95) | p value for interaction 0.036 |
COVID-19 infection, factors in AIRD
- Older age (≥70 years) and GC use significantly associated with lower infection rate
Original publication
COVID-19 infection and efficacy of vaccination in patients with rheumatic diseases during Omicron outbreak in South Korea: a prospective cohort study. RMD Open. Published 16 November 2023. doi:10.
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