Corticosteroid Injections and Risk of Fracture
Main finding · Fracture risk by cumulative CSI doseResult — go to the resultAdjusted hazard ratio 1.04 95% CI 0.96–1.11Authors' conclusion
In this cohort study of cumulative injected corticosteroid dose and risk of subsequent fracture, no association was observed, including in patients with a preexisting diagnosis of osteoporosis.
Study context
- Population
- Adults receiving any CSI, May 1, 2018–July 1, 2022, residing in Olmsted County, Minnesota, empaneled for primary care within the Mayo Clinic346 (4.8%) new fractures
- Participants
- 7,197 adults
- Exposure
- Risk of fracture by cumulative injected corticosteroid dose
- Outcome
- Risk of fracture by total triamcinolone equivalents received
Methodological detailsCox proportional hazards regression
- Cox proportional hazards regression
Main finding
Fracture risk by cumulative CSI dose
Adjusted hazard ratio
1.04
95% CI 0.96–1.11
Cumulative CSI dose
aHR 1.04 (95% CI 0.96–1.11)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Fracture risk by cumulative CSI dose, non-high-risk subgroup
| aHR (95% CI) | ||
|---|---|---|
| Non-high-risk | 1.11 (0.98–1.26) | |
| 0.512Adjusted hazard ratio (log scale) |
Fracture risk by cumulative CSI dose, osteoporosis subgroup
| aHR (95% CI) | ||
|---|---|---|
| Osteoporosis | 1.01 (0.90–1.11) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Corticosteroid Injections and Risk of Fracture. JAMA Netw Open. Published 1 May 2024. doi:10.
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