Correlation of high-resolution computed tomography and immunological bronchoalveolar lavage in interstitial lung disease at the onset of inflammatory rheumatic diseases: implications for diagnosis and therapeutic strategies
Authors' conclusion
In patients with new-onset IRD and ILD, inflammatory pulmonary changes are predominate, reflected by GGO on HRCT and a mainly lymphocytic cell profile in the immunological BAL. In NSIP or UIP on HRCT, the percentages of lymphocytes and neutrophils were higher in BAL fluid, representing a fibrotic component in addition to the inflammation.
Study context
- Population
- Patients with newly diagnosed inflammatory rheumatic diseases and interstitial lung disease (ILD) on HRCT (ground-glass opacities (GGO), non-specific interstitial pneumonia (NSIP) or usual interstitial pneumonia (UIP) pattern), no immunosuppressive therapy
- Participants
- 74 patients
- Exposure
- GGO vs NSIP vs UIP
- Outcome
- Correlation between HRCT findings and immunological BAL patterns (ATS guideline)
Main finding
As reported in the abstract
HRCT and BAL pattern distribution and correlation
- HRCT pattern NSIP
- 47.3%
- HRCT pattern GGO
- 33.8%
- HRCT pattern UIP
- 18.9%
- Bronchoalveolar lavage (BAL) lymphocytic cellular pattern
- 41.9%
- BAL neutrophilic cellular pattern
- 23.0%
- BAL eosinophilic cellular pattern
- 18.9%
- BAL unspecific cellular pattern
- 16.2%
- Lymphocytic BAL pattern most common with GGO on HRCT
- 48%
Observational data: associations, not effects.
Original publication
Correlation of high-resolution computed tomography and immunological bronchoalveolar lavage in interstitial lung disease at the onset of inflammatory rheumatic diseases: implications for diagnosis and therapeutic strategies. Arthritis Res Ther. Published 29 July 2024. doi:10.
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