Vasculitis & polymyalgia rheumatica
Coronary artery calcification in Takayasu's arteritis: clinical characteristics and risk factors
Authors' conclusion
Glucocorticoid usage significantly escalates the risk of CAC.
Study context
- Population
- Patients with TAK
- Participants
- 155 patients
- Exposure
- TAK patients with coronary artery calcification (CAC) vs without CAC
- CACn = 41
- Without CACn = 114reference
- Outcome
- Prevalence and severity of CAC (Agatston score by CCTA)
Methodological detailsCAC measured by Agatston score on coronary computed tomography angiography (CCTA)
- CAC measured by Agatston score on CCTA
Main finding
As reported in the abstract
Prevalence of CAC
CAC
26.45%
41
Observational data: associations, not effects.
Further findings
Independent risk factors for CAC in TAK
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age of onset | 1.084 (1.028–1.142) | P = 0.003 | |
| Disease duration | 1.005 (1.001–1.010) | P = 0.020 | |
| History of hypertension | 4.792 (1.713–13.411) | P = 0.003 | |
| History of hyperlipidaemia | 4.199 (1.087–16.219) | P = 0.037 | |
| Numano V | 3.287 (1.070–10.100) | P = 0.038 | |
| GC use | 3.558 (1.269–9.977) | P = 0.016 | |
| 0.050.21520Odds ratio (log scale) |
CAC and disease activity
- CAC was not associated with disease activity
Calcification score and traditional CV risk factors
- Calcification score positively correlated with number of traditional CV risk factors
Original publication
Coronary artery calcification in Takayasu's arteritis: clinical characteristics and risk factors. Clin Exp Rheumatol. Published 7 August 2023. doi:10.
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