Convergence and divergence in Kawasaki disease and multisystem inflammatory syndrome in children: results from the COVASAKI survey
Authors' conclusion
The demographic and clinical differences between KD e MIS-C cohorts confirm previous reported data.
Study context
- Population
- Children with Kawasaki disease (KD) or MIS-C
- Participants
- 87 children
- Exposure
- KD vs MIS-C
- KDn = 43
- MIS-Cn = 44
- Outcome
- Demographic and clinical differences, KD vs MIS-C
Methodological detailsCOVASAKI survey, prospective data collection, multiple linear regression (MIS-C group)
- COVASAKI survey
- Prospective data collection
- Multiple linear regression (MIS-C group)
Main finding
As reported in the abstract
- Age higher in MIS-C than KD (mean 31±23 vs. 94±50 months, as printed)
- p<0.001
- Extremities abnormalities more often in KD
- p=0.027
- Mucosal involvement more often in KD
- p<0.001
- Irritability more often in KD
- p<0.001
- Gallbladder hydrops more often in KD
- p=0.01
- Lymphadenopathy more often in KD
- p=0.07
- Neurological findings more frequent in MIS-C
- p=0.002
- GI symptoms more frequent in MIS-C
- p=0.013
- Respiratory involvement more frequent in MIS-C
- p=0.019
- Splenomegaly more frequent in MIS-C
- p=0.026
- Cardiac manifestations higher in MIS-C
- p<0.001
- Coronary aneurysms more frequent in KD
- p=0.012
Observational data: associations, not effects.
Further findings
Biomarkers at onset and clinical features (MIS-C, multiple linear regression) · disease onset
- Higher interferon (IFN) score related to myocardial dysfunction
- P < 0.001
- Higher IFN score related to lymphadenopathy
- P = <0.001
- Higher IFN score related to need of ventilation
- P = 0.024
- CXCL9 and CXCL10 related to myocardial dysfunction
- P < 0.001 and p=0.029
- IL18 positively associated with PICU admission
- 0.030
- IL18 positively associated with ventilation
- P = 004
- IL18 negatively associated with lymphadenopathy
- 0.004
- IFNγ related to neurological involvement and lymphadenopathy
- P < 0.001
- IL1b related to heart involvement
- 0.006
- IL6 negatively correlated with heart involvement
- P = 0.013
- IL6 negatively correlated with PICU admission
- P < 0.001
Original publication
Convergence and divergence in Kawasaki disease and multisystem inflammatory syndrome in children: results from the COVASAKI survey. Clin Exp Rheumatol. Published 29 April 2024. doi:10.
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