Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation Is Associated With Immunoglobulin Skewing in Blood
Authors' conclusion
High-resolution automated identification and quantification of synovial immune cell aggregates uncovered skewing in the synovium from naïve IGHD and IGHM to memory IGHG3 and IGHG1 and revealed that this process is reflected in the blood of patients with high inflammatory synovium.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) with synovial tissue
- Participants
- 156 vs 149
- Comparison
- RA vs OA synovium
- RAn = 156
- OAn = 149reference
- Outcome
- Computer vision synovial features (cell density and aggregates)
Methodological detailscomputer vision pipeline
- Computer vision pipeline
Main finding
As reported in the abstract
- All five features associated with pathologist scores of synovial lymphocytic inflammation
- P < 0.0001
Further findings
Blood immunoglobulin genes in RA with high synovial lymphocytic infiltrates
- Relative decrease in IGHGM
- P < 0.002
- Relative decrease in IGHD
- P < 0.03
- Increase in IGHG3
- P < 0.03
- Increase in IGHG1
- P < 0.002
Original publication
Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation Is Associated With Immunoglobulin Skewing in Blood. Arthritis Rheumatol. Published 15 November 2023. doi:10.
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