A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individuals
Authors' conclusion
Radiographic hip and knee OA exhibit distinct patterns of interrelationship, associations with symptoms and risk factors, suggesting heterogeneity in disease processes and the need for joint-specific treatment.
Study context
- Population
- UK Biobank participants with hip and knee DXA scans (mean age 65 years; range 45–85; 52.8% female)
- Participants
- 59,475 participants
- Outcome
- Prevalence of radiographic hip osteoarthritis (OA) (rHOA) and knee OA (rKOA), defined as custom grades ≥2
Methodological detailsmachine learning applied to hip and knee DXA scans, logistic regression, adjusted for age, sex, race, height, weight and deprivation
- Machine learning applied to hip and knee DXA scans
- Logistic regression
- Adjusted for age, sex, race, height, weight and deprivation
Main finding
As reported in the abstract
rHOA prevalence, right side
4098
6.9%
rHOA prevalence, left side
4841
8.1%
rKOA prevalence, right side
3750
6.3%
rKOA prevalence, left side
4220
7.1%
Observational data: associations, not effects.
Further findings
Concurrent joint pain by number of joints with Radiographic OA (rOA) (four joints)
| OR (95% CI) | ||
|---|---|---|
| Four joints with rOA | 4.3 (2.6–7.2) | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Estimate |
|---|---|
| Bilateral associations (joint interrelationships)Knee (bilateral) | 26.1 (CI 24.1–28.2) |
| Bilateral associations (joint interrelationships)Hip (bilateral) | 5.6 (CI 5.2–6.1) |
| Association of BMI with rOABMI, rKOA | 1.57 (CI 1.52–1.61) |
| Association of BMI with rOABMI, rHOA | 1.05 (CI 1.02–1.09) |
Concurrent joint pain by number of joints with rOA (four joints)
- Increasing rOA grades and number of joints affected more strongly associated with concurrent joint pain
Bilateral associations (joint interrelationships)
- Cross-joint (hip-knee) associations were weaker
Association of height with rOA
- Greater height positively associated with rHOA but appeared protective for rKOA
Original publication
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