Lupus & antiphospholipid syndrome
Comparison of carotid intima-media thickness and cognitive function in systemic lupus erythematosus patients versus healthy subjects
Authors' conclusion
SLE patients have lower orientation domain of MoCA-Ina and thicker CIMT than healthy subjects. Atherosclerosis plaque of the carotid artery was associated with attention and visuospatial domains of MoCA-Ina.
Study context
- Population
- SLE patients and healthy subjects undergoing carotid Doppler US and cognitive function testing
- Exposure
- SLE patients vs healthy subjects
- SLEn = Sixty
- HSn = 61reference
- Outcome
- Carotid Intima-media Thickness (CIMT) and MoCA-Ina scores
Main finding
As reported in the abstract
- SLE vs HS: P = 0.332
- SLE vs HS: P < 0.001
- SLE vs HS: P = 0.031
- SLE vs HS: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | SLE | HS | P value |
|---|---|---|---|
| MoCA-Ina orientation domainStatistically lower in SLE | 5.83 ± 0.41 | 6 ± 0.00 | P = 0.002 |
- Correlation of total Montreal Cognitive Assessment IndonesianVersion (MoCA-Ina) score with posterior IMT of left carotid artery (SLE patients)
- −0.272 · r · p p = .035
Right carotid atherosclerosis plaque and MoCA-Ina domains
- Association with attention domain
- P = 0.023
- Association with visuospatial domain
- P = 0.018
- Not associated with total MoCA-Ina score
Original publication
Comparison of carotid intima-media thickness and cognitive function in systemic lupus erythematosus patients versus healthy subjects. Lupus. Published 17 May 2025. doi:10.
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