Strong correlation between SLEDAI and SLE-DAS in the Spanish population: Assessment of discordant patients

Heras-Recuero, E; García-Fernández, A; Blázquez-Sánchez, T; Gómez-Moreno, C; Ferraz-Amaro, I; Llorca, J; González-Gay, MA

doi:10.1016/j.semarthrit.2025.152758

Lupus & antiphospholipid syndrome

Strong correlation between SLEDAI and SLE-DAS in the Spanish population: Assessment of discordant patients

Semin Arthritis RheumPublished 16 May 2025Retrospective cohort study

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Authors' conclusion

SLEDAI-2 K and SLE-DAS demonstrate a strong correlation and high reproducibility for assessing disease activity in the Spanish population.

Study context

Population: Systemic lupus erythematosus (SLE) patients followed up from 2010 to 2024 at Fundación Jiménez Díaz Hospital, Madrid, Spain; data from most recent visits
Participants: 324 patients

Exposure: SLEDAI-2K vs SLE-DAS for disease activity classification
Outcome: Correlation between SLEDAI-2K and SLE-DAS and factors leading to discordance in disease activity classification

Methodological detailssingle-centre

Single-centre

Main finding

As reported in the abstract

Correlation and concordance between SLEDAI-2K and SLE-DAS

ρ

0.970

P < 0.001

SLEDAI-2 K vs SLE-DAS

Linearly weighted Kappa index

0.7715

P < 0.001

SLEDAI-2 K vs SLE-DAS

Patients discordant in disease activity categorization: 44
Discordant at only one level of disease activity: 39
SLE-DAS classified higher activity than SLEDAI-2K (of 44 discordant): 37

Observational data: associations, not effects.

Further findings

Remission

SLEDAI-2 K78.4 %

SLE-DAS78.3 %

Low activity

SLEDAI-2 K13.0 %

SLE-DAS4.3 %

Mild activity

SLEDAI-2 K5.9 %

SLE-DAS14.2 %

Moderate activity

SLEDAI-2 K2.2 %

SLE-DAS0.9 %

Severe activity

SLEDAI-2 K0.6 %

SLE-DAS2.2 %

Remission: SLEDAI-2K: clinical SLEDAI-2K = 0; SLE-DAS: clinical SLE-DAS = 0 regardless of serology and prednisone up to 5 mg/day
Low activity: SLEDAI-2K 1-4 and prednisone ≤ 5 mg/day; SLE-DAS >0 and ≤ 2.48 with prednisone ≤ 7.5 mg/day
Mild activity: SLEDAI-2K 1-4 and prednisone > 5 mg/day or score 5-6; SLE-DAS >0 and ≤ 2.48 with prednisone > 7.5 mg/day or score >2.48 and ≤7.64
Moderate activity: SLEDAI-2K 7-12; SLE-DAS >7.64 and ≤9.9
Severe activity: SLEDAI-2K > 12; SLE-DAS >9.9

Original publication

Strong correlation between SLEDAI and SLE-DAS in the Spanish population: Assessment of discordant patients. Semin Arthritis Rheum. Published 16 May 2025. doi:10.1016/j.semarthrit.2025.152758

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