Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up
Authors' conclusion
Enhanced risk of multiple concurrent disorders was observed both pre- and post-RA Dx, with varying patterns across different disease groups.
Study context
- Population
- All available healthcare claims for Poland, 2011–2021; prevalent rheumatoid arthritis (RA) examined for morbidity patternsmatched 1:10 · prevalent RA 262,265
- Comparison
- Incident RA vs matched controls from the general population
- Incident RAn = 15,879
- Outcome
- Risk of concurrent disorders pre- and post-RA Dx
- Follow-up
- Five years before and after Dx
Methodological detailsretrospective, nationwide, age-, sex- and region-matched controls 1:10, bidirectional five-year follow-up
- Retrospective
- Nationwide
- Age-, sex- and region-matched controls 1:10
- Bidirectional five-year follow-up
Main finding
As reported in the abstract
Risk of concomitant disorders pre- and post-Dx, by disease group · bidirectional 5-year timeframe from RA Dx
RAIncidence rate ratio (95% CI)
Hematologic conditions
1.80(1.58–2.05)
Pulmonary conditions
1.57(1.53–1.62)
Gastrointestinal conditions
1.53(1.46–1.60)
Cardiovascular conditions
1.25(1.22–1.27)
Observational data: associations, not effects.
Further findings
ILD, pre- and post-Dx
| IRR (95% CI) | ||
|---|---|---|
| RApre-Dx | 2.97 (2.20–4.02) | |
| RApost-Dx | 4.66 (3.91–5.56) | |
| 0.20.5125Incidence rate ratio (log scale) |
Inflammatory bowel disease, pre- and post-Dx
| IRR (95% CI) | ||
|---|---|---|
| RApre-Dx | 1.61 (1.25–2.07) | |
| RApost-Dx | 2.12 (1.70–2.63) | |
| 0.20.5125Incidence rate ratio (log scale) |
Thyroid cancer, post-Dx
| IRR (95% CI) | ||
|---|---|---|
| RA | 1.29 (1.00–1.66) | |
| 0.512Incidence rate ratio (log scale) |
Lymphoma, post-Dx
| IRR (95% CI) | ||
|---|---|---|
| RA | 1.50 (1.20–1.88) | |
| 0.512Incidence rate ratio (log scale) |
Colon cancer, post-Dx (reduced risk)
| IRR (95% CI) | ||
|---|---|---|
| RA | 0.77 (0.62–0.94) | |
| 0.512Incidence rate ratio (log scale) |
Original publication
Comorbidity in incident rheumatoid arthritis: a nationwide case-control study with bidirectional follow-up. Rheumatology (Oxford). Published 17 December 2024. doi:10.
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