Higher risk of poor functional outcome and unfavourable clinical events for late-onset rheumatoid arthritis: results from the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) cohort
Authors' conclusion
Patients with LORA and YORA exhibited similar improvements in disease activity over 5 years; however, those with LORA demonstrated a more pronounced decline in physical function.
Study context
- Population
- Patients diagnosed with early RA (disease duration < 2 years) between 2000 and 2016 in the IORRA cohort
- Participants
- 813 vs 2,457
- Exposure
- Late-onset RA vs younger-onset RA
- Late-onset RA (LORA)n = 813
- Younger-onset RA (YORA)n = 2,457reference
- Outcome
- Co-primary: changes in Clinical Disease Activity Index (CDAI) and J-HAQ
- Follow-up
- Year 5
Methodological detailsobservational cohort (IORRA)
- Observational cohort (IORRA)
Main finding
As reported in the abstract
CDAI, mean score
LORA
4.39
mean
YORA
4.03
mean
Observational data: associations, not effects.
Secondary outcomes
Mean
| Outcome | LORA | YORA |
|---|---|---|
| Co-primary: J-HAQ, mean score · Year 5 | 0.56 | 0.33 |
Co-primary: J-HAQ, mean score · Year 5
- J-HAQ for YORA remained stable below 0.5 after Year 2, whereas that for LORA worsened progressively
Safety
| Outcome | Estimate |
|---|---|
| Prespecified adverse eventsLORA vs YORA | aHR for death 4.70 |
| Prespecified adverse eventsLORA vs YORA | aHR for malignancy 2.58 |
Prespecified adverse events
- Higher incidence of adverse events with LORA
Original publication
Higher risk of poor functional outcome and unfavourable clinical events for late-onset rheumatoid arthritis: results from the IORRA cohort. Rheumatology (Oxford). Published 16 December 2024. doi:10.
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