Cancer Incidence and Outcome for Patients With Rheumatoid Arthritis: A Long-term Population Study in Western Australia
Main finding · Overall post-index CIR per 1000 person-years, participants without prior cancerResult — go to the resultIncidence rate ratio 0.79 95% CI 0.76–0.83Authors' conclusion
Overall CIR in patients with RA was consistently lower over time than in matched controls. CIR was only increased for lung and hematological cancer. Despite the overall lower CIR, post cancer mortality was higher for patients with RA in most cancer subtypes.
Study context
- Population
- Hospitalised patients in the Hospital Morbidity Data Collection, Western Australia, 1985–2015matched cohort
- Participants
- 14,041 vs 33,785
- Exposure
- Hospitalised patients with rheumatoid arthritis (RA) vs matched nonexposed hospitalised controls
- RAn = 14,041
- Controlsn = 33,785reference
- Outcome
- Post-index cancer incidence (CIR per 1000 person-years) in participants without prior cancer
Methodological detailspopulation-level observational study, matched on sex, age and year of index admission, linked hospital, cancer and death registry data
- Population-level observational study
- Matched on sex, age and year of index admission
- Linked hospital, cancer and death registry data
Main finding
As reported in the abstract
Overall post-index CIR per 1000 person-years, participants without prior cancer
Incidence rate ratio
0.79
95% CI 0.76–0.83
By group
RAvs Controls
IRR 0.79 (95% CI 0.76–0.83)
Observational data: associations, not effects.
Further findings
Preexisting cancer prevalence
P < 0.01
Overall median survival
P < 0.001
| Outcome | Estimate |
|---|---|
| CIR by cancer type in RA vs controlsHigher in RA | CIR (lung cancer) 1.17 (95% CI 1.04–1.34) |
| CIR by cancer type in RA vs controlsHigher in RA | CIR (hematological cancer) 1.21 (95% CI 1.03–1.43) |
CIR by cancer type in RA vs controls
- CIR lower in RA for most other cancer types
Overall median survival
- Increased mortality rates in RA for most cancer subtypes
Original publication
Cancer Incidence and Outcome for Patients With Rheumatoid Arthritis: A Long-term Population Study in Western Australia. J Rheumatol. Published 15 December 2024. doi:10.
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