Spondyloarthritis & psoriatic arthritis
Comorbidities in Early Psoriatic Arthritis: Data From the Metabolic Disturbances in Psoriatic Arthritis Cohort Study
Main finding · CV risk factorsResult — go to the resultOdds ratio 1.6 95% CI 1.14–2.0Authors' conclusion
Our data imply that patients with PsA already have higher comorbidities and CV burden at early stages of the disease, suggesting that these are not only a consequence of long-lasting disease and chronic systemic inflammation.
Study context
- Population
- Treatment-naive patients with early psoriatic arthritis (PsA) and sex- and age-matched healthy volunteers
- Participants
- 67 vs 61
- Exposure
- Treatment-naive early PsA vs sex- and age-matched healthy controls
- Early psoriatic arthritis (ePsA)n = 67
- Controlsn = 61reference
- Outcome
- Prevalence of comorbidities and CV risk factors
- Follow-up
- Baseline
Methodological detailsobservational, longitudinal, multicentre, sex- and age-matched controls
- Observational
- Longitudinal
- Multicentre
- Sex- and age-matched controls
Main finding
CV risk factors
Odds ratio
1.6
95% CI 1.14–2.0
By group
ePsAvs Healthy controls
OR 1.6 (95% CI 1.14–2.0)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | ePsA | Controls | OR (95% CI) | |
|---|---|---|---|---|
| Multiple (≥2) comorbidities · baseline | 1.9 (1.2–3.0) | |||
| Multiple CV RFs · baseline | 2.1 (1.3–3.2) | |||
| Obesity · baseline | 40.3% | 18.3% | 1.9 (1.1–3.2) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | ePsA | Controls |
|---|---|---|
| BMI · baselineAbove normal on average | mean 28.82 (SD 4.5) | — not stated in the abstract |
— not stated in the abstract
Dyslipidemia (most prevalent comorbidity) · baseline
- Dyslipidemia, PsA cohort vs controls
- 64.2% vs 39.3%; OR 1.7, 95% CI 1.2-2.5
Comorbidities or CV risk factors (RFs) by duration of skin psoriasis
- Not influenced by duration of skin psoriasis
Comorbidities and CV RFs after 1 year
- Proportion of patients with comorbidities and CV RFs did not increase or drop, although disease activity scores improved
Original publication
Comorbidities in Early Psoriatic Arthritis: Data From the Metabolic Disturbances in Psoriatic Arthritis Cohort Study. Arthritis Care Res (Hoboken). Published 15 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →