Combination of scavenger receptor-A with anti-cyclic citrullinated peptide antibody for the diagnosis of rheumatoid arthritis
Performance · Diagnostic accuracy for RAResult — go to the resultIncrease in sensitivity 13%Authors' conclusion
SR-A and anti-CCP dual combination could potentially improve early diagnosis of RA
Study context
- Population
- RA patients, healthy controls and patients with other common rheumatic diseases, from three cohorts
- Participants
- 1,129 patients3 cohorts
- Comparison
- Scavenger receptor-A (SR-A) and anti-CCP dual combination vs anti-CCP alone for RA diagnosis
- Outcome
- Diagnostic performance for RA (covariate-adjusted ROC, sensitivity, specificity, clinical association)
Methodological detailsmulticentre, large-scale, pilot study then validation, covariate-adjusted ROC
- Multicentre
- Large-scale
- Pilot study then validation
- Covariate-adjusted ROC
Performance
Diagnostic accuracy for RA
Increase in sensitivity
13%
By group
SR-A + anti-CCP
- Sensitivity
- 87%
- Specificity
- 90%
anti-CCP
74%
sensitivity
As reported in the abstract
Further findings
Diagnostic accuracy in early RA (subgroup)
increase in sensitivity 7%
Sensitivity
Specificity SR-A + anti-CCP 94%
Clinical association
- SR-A and anti-CCP dual combination correlated with ESR, IgM and autoantibodies of RA patients
Original publication
Combination of scavenger receptor-A with anti-cyclic citrullinated peptide antibody for the diagnosis of rheumatoid arthritis. Rheumatology (Oxford). Published 23 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →