Clinical insights into heterogeneity of rheumatoid factor negative polyarticular juvenile idiopathic arthritis across the world
Authors' conclusion
Our results confirm the wide heterogeneity of the clinical presentation and outcome of children with RF-negative polyarticular JIA throughout the world. In particular, relevant differences in the onset age were observed across geographic areas. The group of children with early onset polyarthritis, ANA positivity, and risk of uveitis is remarkably frequent in Southern Europe.
Study context
- Population
- Patients with rheumatoid factor (RF)-negative polyarticular juvenile idiopathic arthritis (JIA) from the multinational EPOCA studyof 9081 in EPOCA
- Participants
- 2,141 patients
- Exposure
- RF-negative polyarticular JIA across geographic areas
- Outcome
- Prevalence of RF-negative polyarthritis
Methodological detailsmultinational, retrospective chart review, cross-sectional evaluation
- Multinational
- Retrospective chart review
- Cross-sectional evaluation
Main finding
As reported in the abstract
Prevalence of RF-negative polyarthritis among EPOCA patients
23.6%
Prevalence lowest in Southeast Asia
12.7%
Early onset + ANA positivity + uveitis mainly in Southern Europe
39%
Observational data: associations, not effects.
Original publication
Clinical insights into heterogeneity of rheumatoid factor negative polyarticular juvenile idiopathic arthritis across the world. Pediatr Rheumatol Online J. Published 19 March 2025. doi:10.
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