Predictors of Clinical Remission in Children With Polyarticular Juvenile Idiopathic Arthritis Treated With Abatacept
Authors' conclusion
Patients who achieve minimal disease activity within 3 months of abatacept treatment are more likely to achieve JADAS ID or CR earlier and maintain it for 24 months, regardless of administration route.
Study context
- Population
- Patients with polyarticular course-juvenile idiopathic arthritis (pc-JIA) treated with intravenous (age 6–17 years) or subcutaneous (age 2–17 years) abatacept347/409 (84.8%) patients included, excluded: 62 patients who switched to placebo · intravenous abatacept trial 128 · subcutaneous abatacept trial 219
- Participants
- 347 patients
- Comparison
- Patients with minimal disease activity at days 57 or 85 vs patients with moderate or high disease activity
- Outcome
- Baseline predictors of JADAS CR (multivariable model)
Methodological detailstime-to-event analyses, Kaplan-Meier analyses, multivariable model
- Time-to-event analyses
- Kaplan-Meier analyses
- Multivariable model
Main finding
As reported in the abstract
HR for JADAS clinical remission (CR)
- Younger age (≤10 years)
- 1.8
- Lower CHAQ-DI (≤0.75)
- 1.8
- Lower parent global assessment values (≤43.16)
- 2.1
- Normal high-sensitivity CRP (<0.21)
- 1.6
Further findings
| Outcome | Estimate |
|---|---|
| JADAS ID · during a 24-month periodMODERATE OR HIGH DISEASE ACTIVITY vs MINIMAL DISEASE ACTIVITY | HR for achieving JADAS ID (disease activity at day 57) 0.2-0.4 |
| JADAS ID · during a 24-month periodMODERATE OR HIGH DISEASE ACTIVITY vs MINIMAL DISEASE ACTIVITY | HR for achieving JADAS ID (disease activity at day 85) 0.2-0.5 |
| JADAS CR · during a 24-month periodMODERATE OR HIGH DISEASE ACTIVITY vs MINIMAL DISEASE ACTIVITY | HR for achieving JADAS CR (disease activity at day 57) 0.1-0.5 |
| JADAS CR · during a 24-month periodMODERATE OR HIGH DISEASE ACTIVITY vs MINIMAL DISEASE ACTIVITY | HR for achieving JADAS CR (disease activity at day 85) 0-0.3 |
- JADAS inactive disease (ID): patients with minimal disease activity more likely to achieve JADAS ID earlier
- JADAS CR: patients with minimal disease activity more likely to achieve CR earlier
Original publication
Predictors of Clinical Remission in Children With Polyarticular Juvenile Idiopathic Arthritis Treated With Abatacept. J Rheumatol. Published 1 November 2026. doi:10.
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