Clinical features, triggers, and risk factors of severe gastrointestinal involvement in anti-NXP2-positive juvenile dermatomyositis: a retrospective cohort study
Authors' conclusion
Infection may be an important trigger. Risk factors for GI complications include severe JDM at onset, malnutrition, skin ulceration, edema, low CMAS score, high CAT-A score, lymphocytopenia, anemia, hypoalbuminemia and elevated ESR.
Study context
- Population
- Anti-NXP2-positive JDM patients
- Participants
- 57 patients
- Exposure
- Anti-NXP2-JDM with severe gastrointestinal (GI) complications vs without GI involvement
- GIn = 19
- Non-GIn = 38reference
- Outcome
- Clinical characteristics, triggers and risk factors for GI complications
Methodological detailsmultivariate analysis, Kaplan-Meier analysis
- Multivariate analysis
- Kaplan-Meier analysis
Main finding
As reported in the abstract
Risk factors for GI complications (multivariate analysis)
- Independent risk factors: severe JDM at onset, infection, malnutrition, CAT-A score, skin ulcer, edema and ESR
- Protective factors: lymphocyte count, proximal muscle strength, CMAS score, hemoglobin and albumin
Observational data: associations, not effects.
Further findings
Deaths
P = 0.002
- Prodromal infections (potential triggers) in GI group
- 84% · 16 of 19
- GI group characteristics
- 5.83 · mean · years
Prodromal infections (potential triggers) in GI group
- All severe GI involvement occurred during active JDM
GI group characteristics
- Abdominal pain the most common initial symptom
Survival (Kaplan-Meier)
- Significantly different survival rates between groups
Original publication
Clinical features, triggers, and risk factors of severe gastrointestinal involvement in anti-NXP2-positive juvenile dermatomyositis: a retrospective cohort study. Pediatr Rheumatol Online J. Published 22 May 2026. doi:10.
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