New epidemiological characteristics of childhood IgA vasculitis in the post-COVID-19 era: a single-center retrospective cohort study
Authors' conclusion
In the post-COVID-19 era, childhood IgAV presents with new clinical characteristics, marked by an increased overall disease burden and a shift towards more severe clinical phenotypes.
Study context
- Population
- Children hospitalized with IgA vasculitis (IgAV), single centre
- Exposure
- Post-COVID-19 era vs Pre-COVID-19
Methodological detailssingle-center, time-series models, multivariate logistic regression
- Single-center
- Time-series models
- Multivariate logistic regression
Main finding
As reported in the abstract
- Disease burden intensified in Post-COVID-19 era: hospitalization duration, costs and proportion of IgAV admissions surged; observed crude hospitalization rate significantly exceeded model predictions
- Among newly-diagnosed cases, renal subtype proportion increased significantly and cutaneous-only form decreased
- Post-COVID-19: significant alterations in humoral immunity and complement profiles, increased Mycoplasma pneumoniae infection
Observational data: associations, not effects.
Further findings
Relapse at 6-month follow-up (newly-diagnosed non-nephritic patients)
- No significant difference in relapse rates between cohorts
Progression to IgA vasculitis nephritis (IgAVN) at 6-month follow-up
- Progression rate to nephritis significantly elevated in Post-COVID-19 group
Independent predictors of IgAVN
- Duration of rash the sole consistent independent predictor across both periods
Original publication
New epidemiological characteristics of childhood IgA vasculitis in the post-COVID-19 era: a single-center retrospective cohort study. Pediatr Rheumatol Online J. Published 19 May 2026. doi:10.
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