Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study
Main finding · NephritisResult — go to the resultOdds ratio 3.1 95% CI 1.04–9.21Authors' conclusion
Patients with IgAV/HSP and severe skin manifestations had a more severe clinical course and more frequently required glucocorticoids compared to classic IgAV/HSP patients.
Study context
- Population
- Pediatric patients with igA vasculitis (IgAV) (formerly HSP), 12 international tertiary university medical centres
- Participants
- 64 vs 596
- Exposure
- IgAV/HSP with severe cutaneous manifestations vs IgAV/HSP without these manifestations
- Severe cutaneous manifestationsn = 64
- Controln = 596reference
- Outcome
- Association of severe skin manifestations with a more severe disease course
Methodological detailsinternational, 12 tertiary university medical centres, multivariate analysis
- International
- 12 tertiary university medical centres
- Multivariate analysis
Main finding
Nephritis
Odds ratio
3.1
95% CI 1.04–9.21
P = 0.042
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Severe GI complications (hematochezia, massive bleeding and/or intussusception) — Severe cutaneous manifestations vs Control
P < 0.001
Need for systemic GC treatment
P < 0.001
Severe GI complications (hematochezia, massive bleeding and/or intussusception)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Severe cutaneous changesMultivariate analysis | 3.65 (1.08–12.37) | P = 0.038 | |
| 0.050.21520Odds ratio (log scale) |
Age at disease onset
P < 0.001
D-dimer concentration
P = 0.003
- Renal disease outcome
- P = 0.001
Age at disease onset
- Patients with severe cutaneous manifestations were older
Renal disease outcome
- Worse outcome of renal disease with severe cutaneous manifestations
Original publication
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