Clinical Features Associated With Rate of Fractures in Patients With Systemic Sclerosis: A US Cohort Study
Main finding · FracturesResult — go to the resultHazard ratio 2.38 95% CI 1.47–3.83Authors' conclusion
Disability as measured by the HAQ DI is a particularly strong indicator of fracture rate in SSc.
Study context
- Population
- Participants with systemic sclerosis (SSc) in FORWARD, The National Databank for Rheumatic Diseases (1998–2019), US; 87% female, mean age 57.8 years51 with ≥1 fracture
- Participants
- 922 participants
- Exposure
- SSc vs age- and sex-matched osteoarthritis (OA) comparators
- SScn = 154
- OAn = 768reference
- Outcome
- Self-reported major osteoporotic fracture
Methodological detailsage- and sex-matched comparators, Cox proportional hazards models
- Age- and sex-matched comparators
- Cox proportional hazards models
Main finding
Fractures · median 4.2 years (0.5-22.0 years) of follow-up
Hazard ratio
2.38
95% CI 1.47–3.83
SScvs OA
HR 2.38 (95% CI 1.47–3.83)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Fracture by Rheumatic Disease Comorbidity Index score (higher), among SSc
| HR (95% CI) | ||
|---|---|---|
| Higher Rheumatic Disease Comorbidity Index score | 1.45 (1.20–1.75) | |
| 0.512Hazard ratio (log scale) |
Fracture by HAQ-DI score (higher), among SSc
| HR (95% CI) | ||
|---|---|---|
| Higher HAQ-DI score | 3.83 (2.12–6.93) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| Fracture with diabetes mellitus or renal disease, among SScDiabetes mellitusvs SSc without diabetes mellitusIndependently associated | 5.89 (2.51–13.82) | |
| Fracture with diabetes mellitus or renal disease, among SScRenal diseasevs SSc without renal diseaseIndependently associated | 2.43 (1.10–5.37) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Clinical Features Associated With Rate of Fractures in Patients With Systemic Sclerosis: A US Cohort Study. Arthritis Care Res (Hoboken). Published 13 July 2023. doi:10.
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