Vasculitis & polymyalgia rheumatica
Clinical features and independent predictors of Behçet's disease associated with myelodysplastic syndrome
Authors' conclusion
Our findings suggest that cytogenetic abnormalities, especially trisomy 8, may play a role in the association of GI involvement, BD, and MDS. GI involvement, low haemoglobin, and high ESR level were independent predictors for MDS development in BD patients.
Study context
- Population
- Chinese patients with Behçet's disease (BD) associated with myelodysplastic syndrome (MDS), First Affiliated Hospital of Zhengzhou University10 females, 5 males (BD-MDS)
- Participants
- 15 / 60 / 60
- Exposure
- BD-MDS vs general BD without MDS; vs primary MDS without BD
- BD-MDSn = 15
- BD without MDSn = 60reference
- Primary MDSn = 60reference
- Outcome
- Clinical features of BD-MDS
Methodological detailssingle-centre, comparison with BD without MDS and with primary MDS without BD, logistic regression
- Single-centre
- Comparison with BD without MDS and with primary MDS without BD
- Logistic regression
Main finding
As reported in the abstract
Abnormal karyotype
13
86.7%
Trisomy 8
11
Gastrointestinal (GI) involvement
10
66.7%
Observational data: associations, not effects.
Further findings
BD-MDS vs BD without MDS
- BD-MDS significantly older; fever and GI involvement more common; lower leukocyte count, haemoglobin and platelet count (p<0.05)
- GI involvement, low haemoglobin and high erythrocyte sedimentation rate (ESR) independently associated with MDS development in BD (logistic regression)
IBD-MDS vs IBD without MDS
- IBD-MDS older, more fever, lower leukocyte count, haemoglobin and platelet count, higher ESR and CRP (p<0.05)
BD-MDS vs primary MDS
- More abnormal karyotypes and more trisomy 8 in BD-MDS (p<0.05)
- Distribution of 2016 WHO MDS subtypes and IPSS-R categories similar
Original publication
Clinical features and independent predictors of Behçet's disease associated with myelodysplastic syndrome. Clin Exp Rheumatol. Published 15 August 2022. doi:10.
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