Clinical characteristics and prognostic factors in adult macrophage activation syndrome: an observational study in a Chinese cohort
Authors' conclusion
Our results indicated that adult MAS patients with lower ferritin levels at admission, lower PLT counts, elevated ALT, CNS involvement and more active infection were associated with an unfavourable prognosis.
Study context
- Population
- Adult inpatients with macrophage activation syndrome meeting HLH-2004 criteria, January 2016 to January 2024, Chinese cohort
- Participants
- 116 inpatients
- Outcome
- In-hospital mortality and its prognostic factors
- Follow-up
- During hospitalisation
Methodological detailsobservational, multivariate logistic regression
- Observational
- Multivariate logistic regression
Main finding
As reported in the abstract
In-hospital mortality
Died during hospitalisation
17 of 116
14.7%
Observational data: associations, not effects.
Further findings
Prognostic factors for mortality (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Admission ferritin <1350 ng/mL | 5.387 (1.203–24.127) | P = 0.034 | |
| PLT ≤30×109/L | 5.387 (1.203–24.127) | P = 0.028 | |
| ALT ≥275 U/L | 5.732 (1.167–28.167) | P = 0.032 | |
| CNS involvement | 11.268 (1.353–93.851) | P = 0.025 | |
| PCT >0.9 ng/mL | 11.224 (2.019–62.381) | P = 0.006 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Clinical characteristics and prognostic factors in adult macrophage activation syndrome: an observational study in a Chinese cohort. Lupus Sci Med. Published 14 October 2025. doi:10.
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