Association of anti-Ro52 antibody with depression and anxiety in patients with connective tissue diseases: an observational, single-centre, cross-sectional study
Main finding · Depression (PHQ-9 ≥ 5): anti-Ro52 antibody as risk factorResult — go to the resultOdds ratio 5.466 95% CI 2.978~10.032Authors' conclusion
Anti-Ro52 antibody is probably a risk factor for depression and anxiety in patients with connective tissue diseases. CTD patients with the presence of anti-Ro52 antibody are more prone to depression and anxiety than those without it.
Study context
- Population
- Inpatients with connective tissue diseases (CTDs)inpatients with CTDs
- Participants
- 352 inpatients
- Exposure
- Anti-Ro52 antibody present vs absent
- CTDn = 352
- Outcome
- Depression (PHQ-9 ≥ 5) and anxiety (GAD-7 ≥5) and their risk factors, especially serum autoantibodies
Methodological detailsobservational, single-centre, logistic regression
- Observational
- Single-centre
- Logistic regression
Main finding
As reported in the abstract
Depression (PHQ-9 ≥ 5): anti-Ro52 antibody as risk factor
Odds ratio
5.466
95% CI 2.978~10.032
P < 0.001
Anti-Ro52 positivevs Anti-Ro52 negative
OR 5.466 (95% CI 2.978~10.032); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Anxiety (GAD-7 ≥5): anti-Ro52 antibody as risk factorAnti-Ro52 positivevs Anti-Ro52 negative | 4.075 (2.073~8.010) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Sleep time as protective factor for depression
| OR (95% CI) | P value | ||
|---|---|---|---|
| Sleep time | 0.734 (0.616~0.874) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Sleep time as protective factor for anxiety
| OR (95% CI) | P value | ||
|---|---|---|---|
| Sleep time | 0.684 (0.559~0.835) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Prevalence of depression and anxiety, CTD patients vs Chinese general population
- Depression: CTD patients vs Chinese general population
- 44.3% vs. 32.2%
- Anxiety: CTD patients vs Chinese general population
- 39.5% vs. 22.2%
- Significantly higher than in the Chinese general population
Anti-Ro52 and depression/anxiety in subgroups (SLE, SS, RA, other CTDs)
- Anti-Ro52 antibody was a risk factor for depression and anxiety in all four subgroups
Original publication
Association of anti-Ro52 antibody with depression and anxiety in patients with connective tissue diseases: an observational, single-centre, cross-sectional study. Clin Exp Rheumatol. Published 25 August 2023. doi:10.
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