Clinical characteristics and prognosis of childhood-onset lupus mesenteric vasculitis as the initial presentation—a case–control study
Authors' conclusion
LMV often occurs in 12 ~ 13-year-old girls with high disease activity of cSLE. Abdominal pain is the most common and more susceptible to damage to the kidney, serous cavity, and lung in cSLE with LMV. Methylprednisolone pulse combined with CTX pulse therapy is effective. After the treatment above, cSLE with LMV has a good prognosis, but the overall recovery is worse than non-LMV patients.
Study context
- Population
- Chinese children with childhood-onset SLE, July 2018–July 2021
- Participants
- 55 children
- Comparison
- cSLE with lupus mesenteric vasculitis (LMV) vs cSLE without LMV
- LMVn = 11
- Non-LMVn = 44reference
- Outcome
- Clinical characteristics, LMV vs non-LMV
Methodological detailsmatched on age and sex
- Matched on age and sex
Main finding
As reported in the abstract
- LMV: average age of onset 12.55 ± 1.57 years; male-to-female ratio 2:9; high disease activity
- Abdominal pain most common in LMV
- LMV vs Non-LMV: P < 0.05
Observational data: associations, not effects.
Further findings
- Deaths — LMV
- 0 events
- Abdominal-enhanced CT findings
- P < 0.05
- Prognosis and follow-up
- P < 0.05
- Abdominal-enhanced CT findings: Higher intestinal wall thickening, peritoneal effusion, mesenteric vascular enhancement, hydronephrosis with ureteral dilatation, intestinal congestion, gastric mucosa thickening in LMV
- Prognosis and follow-up: Higher 24-h urinary protein, lower complement C3, higher disease activity in LMV
Treatment
- Methylprednisolone pulse plus CYC pulse therapy more frequent in LMV than non-LMV
Prognosis and follow-up
- Clinical symptoms disappeared quickly in LMV
Original publication
Clinical characteristics and prognosis of childhood-onset lupus mesenteric vasculitis as the initial presentation—a case–control study. Arthritis Res Ther. Published 20 December 2023. doi:10.
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