Lupus & antiphospholipid syndrome
Clinical and histopathological predictors of systemic lupus erythematosus in a South American cohort of patients with full-house glomerulonephritis
Authors' conclusion
In this South American cohort, 35.9% of FHGN were not associated with SLE diagnosis. Female sex, younger age, positive ANA or anti-DNA antibodies and marked C1q deposits at renal biopsy were associated with SLE diagnosis.
Study context
- Population
- South American cohort with full-house glomerulonephritis (GN) on kidney biopsy, 2000–2019124 women (68.5%)
- Participants
- 181 participants
- Exposure
- Lupus-FHGN vs non-Lupus FHGN
- Lupus - FHGNn = 116
- Outcome
- Clinical and renal histopathological variables associated with SLE diagnosis in FHGN
Methodological detailsobservational, single-centre biopsy review 2000–2019, univariate and multivariate logistic regression, Kaplan-Meier renal survival, Median post-biopsy follow-up 2.9 years (IQR 0.4-6.8 years); mean age 41.1 years (SD 16.0)
- Observational
- Single-centre biopsy review 2000–2019
- Univariate and multivariate logistic regression
- Kaplan-Meier renal survival
- Median post-biopsy follow-up 2.9 years (IQR 0.4-6.8 years); mean age 41.1 years (SD 16.0)
Main finding
As reported in the abstract
Factors associated with Lupus-FHGN (multivariate analysis)
- 3 or 4 crosses of IgG, C3 and C1q deposits more frequent in Lupus-FHGN
- p < 0.001
- Less moderate/severe tubulointerstitial involvement in Lupus-FHGN
- p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| ESRDUnivariate analysis | 0.34 (0.13–0.89) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | Lupus - FHGN |
|---|---|
| Patients meeting SLE criteria | 64.1% |
- Patients meeting Systemic Lupus Erythematosus (SLE) criteria — Extrarenal manifestations
- 103
- Patients meeting SLE criteria — Renal-limited lupus
- 13
- Patients meeting SLE criteria — Identifiable secondary causes of FHGN
- 52
- Patients meeting SLE criteria — Idiopathic FHGN
- 13
End-Stage Renal Disease (ESRD)
- Association not significant in the multivariate analysis
Original publication
Clinical and histopathological predictors of systemic lupus erythematosus in a South American cohort of patients with full-house glomerulonephritis. Lupus. Published 23 June 2026. doi:10.
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