Lupus & antiphospholipid syndrome
Lupus or not? Idiopathic full house glomerulonephritis: a rare nephropathy with unexpectedly severe outcome
Authors' conclusion
All patients with iFH-N had similar clinical presentation, appeared to be refractory to aggressive IS, and had poor renal outcome.
Study context
- Population
- Patients with kidney biopsies showing full-house immunofluorescence pattern, 2012–2022of 2210 biopsied
- Participants
- 5 patients
- Outcome
- Clinical presentation, renal outcome and development of SLE in the long term
Methodological detailscase series, All received aggressive immunosuppression: steroids, CYC, MMF or Intensified B Cell Depletion Protocol
- Case series
- All received aggressive immunosuppression: steroids, CYC, MMF or Intensified B Cell Depletion Protocol
Main finding
As reported in the abstract
Renal outcome · mean follow-up 7.4 year (SD ± 2.4)
- Developed end stage renal disease
- Four patients (80%)
- ESRD within 24 months
- three
- CKD stage 4
- one patient
- Developed systemic lupus erythematosus (SLE) after two years
- One subject
Observational data: associations, not effects.
Further findings
Serum creatinine at presentation, mean
- Mean serum creatinine
- 2.1 mg/dl (SD± 0.47)
eGFR at presentation, mean
- Mean eGFR
- 35.2 ml/min/1.73m2 (SD±11)
Proteinuria at presentation, mean
- Mean proteinuria
- 7.1 gr/24h (SD±3.2)
Development of SLE · after two years
- Patients who developed SLE
- 1
Original publication
Lupus or not? Idiopathic full house glomerulonephritis: a rare nephropathy with unexpectedly severe outcome. Clin Exp Rheumatol. Published 5 December 2024. doi:10.
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