Spondyloarthritis & psoriatic arthritis
Clinical and genetic factors associated with radiographic damage in patients with ankylosing spondylitis
Authors' conclusion
This study identified clinical and genetic factors that contributed to better understanding of the pathogenesis and biology associated with radiographic damage in AS.
Study context
- Population
- Patients with ankylosing spondylitis (AS)
- Participants
- 444 patients
- Outcome
- Severe radiographic damage (final mSASSS)
Methodological detailsgenome-wide SNP data, multiple linear regression, functional validation in osteoprogenitor cells
- Genome-wide SNP data
- Multiple linear regression
- Functional validation in osteoprogenitor cells
Performance
As reported in the abstract
Factors associated with final mSASSS / severe radiographic damage
- Baseline modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) (β=0.796)
- p=3.22×10-75
- Peripheral joint arthritis (β=−0.246)
- p=6.85×10-6
- Uveitis (β=0.157)
- p=1.95×10-3
- Smoking (β=0.130)
- p=2.72×10-2
- RYR3 gene associated with severe radiographic damage, after adjusting for significant clinical factors
- p=1.00×10-6
- PI3K-Akt signalling pathway associated with severe radiographic damage (false discovery rate=0.040)
- p=2.21×10-4
Further findings
Functional validation
- Rhodamine B (RYR3 ligand) dose-dependently induced matrix mineralisation of AS osteoprogenitors
- Rhodamine B-induced accelerated matrix mineralisation not definitive in control osteoprogenitors
- Knockdown of RYR3 inhibited matrix mineralisation in SaOS2 cell lines
Original publication
Clinical and genetic factors associated with radiographic damage in patients with ankylosing spondylitis. Ann Rheum Dis. Published 21 December 2022. doi:10.
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