Clinical and diagnostic characteristics of arterial involvement in paediatric Behçet's disease
Authors' conclusion
Paediatric BD with arterial involvement is a severe phenotype with a poor prognosis, characterized by intense inflammation and multi-organ damage.
Study context
- Population
- Paediatric Behçet's disease (BD) patients, January 2013 - May 2024
- Participants
- 76 patients
- Exposure
- Paediatric BD with arterial involvement vs without vascular involvement
- Experimentaln = 19
- Controln = 57reference
- Outcome
- Arterial involvement characteristics (experimental group)
Main finding
As reported in the abstract
- Medium-sized arteries
- 15/19, 78.95%
- Large-sized arteries
- 13/19, 68.42%
- Both medium- and large-sized arteries
- 9/19, 47.37%
- Abdominal aorta
- 8/19, 42.11%
- Pulmonary artery
- 7/19, 36.84%
- Femoral artery
- 7/19, 36.84%
- Wall thickening
- 9/19, 47.37%
- Lumen dilation
- 8/19, 42.11%
- Stenosis
- 7/19, 36.84%
Observational data: associations, not effects.
Further findings
Onset age, arterial involvement vs control
- Later onset age, experimental vs control group (years)
- 11.0 vs. 7.0
Disease duration, arterial involvement vs control
- Shorter disease duration, experimental vs control group (months)
- 6.0 vs. 24.0
Clinical and laboratory features, arterial involvement vs control
- Higher incidences of fever, multi-organ involvement (neurological, renal, cardiac) and elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in the experimental group
- More intensive treatment and surgery in the experimental group
Mortality, arterial involvement vs control
- Significantly higher mortality, experimental vs control group
- 10.53% vs. 0%
Safety
Cerebrovascular accidents, arterial involvement vs control
- Significantly higher rate, experimental vs control group
- 15.79% vs. 0%
Cardiac complications, arterial involvement vs control
- Significantly higher rate, experimental vs control group
- 31.58% vs. 0%
Original publication
Clinical and diagnostic characteristics of arterial involvement in paediatric Behçet's disease. Clin Exp Rheumatol. Published 4 November 2025. doi:10.
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