Paediatric neuro-Behçet’s disease: multi-centre observational study
Authors' conclusion
The non-parenchymal subgroup is the predominant form in children.
Study context
- Population
- Paediatric patients diagnosed with neuro-Behçet's disease (NBD)
- Participants
- 75 patients
- Exposure
- Nonparenchymal vs Parenchymal vs Mixed
- Nonparenchymaln = 56
- Parenchymaln = 15
- Mixedn = 4
- Outcome
- Neurologic manifestations of paediatric NBD
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
- Neurologic manifestations at initial presentation
- 52 (69.3%)
- Neurologic manifestations after diagnosis
- 23 (30.7%)
- Median time to neurologic manifestations after diagnosis, months (range as printed)
- 14 (8-30)
- Headache (most common neurological symptom)
- 70 (93.3%)
- Headache more frequent in non-parenchymal form
- P = 0.028
- Paresis more frequent in parenchymal form
- P = 0.034
- Sensory loss more frequent in parenchymal form
- P = 0.016
- Mood/mental health problems more frequent in parenchymal form
- P = 0.005
- Parenchymal lesions on neuroimaging
- 19 (25.3%)
- Vascular lesions on neuroimaging
- 55 (73.3%)
Observational data: associations, not effects.
Further findings
Treatment and outcome
- AZA, the most commonly used immunosuppressor therapy
- 78.7%
- Median follow-up, months
- 30 (17.5-52.5)
- Significant clinical improvement during follow-up
Deaths · during follow-up
- No deaths reported
Original publication
Paediatric neuro-Behçet’s disease: multi-centre observational study. Rheumatology (Oxford). Published 11 April 2026. doi:10.
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