Vasculitis & polymyalgia rheumatica
Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis
Authors' conclusion
cTph cells are expanded and exhibit an activated, pro-inflammatory profile with a cTph2-skewed distribution in active GPA-patients.
Study context
- Population
- Patients with granulomatosis with polyangiitis (GPA) in remission or active disease and age- and sex-matched healthy controlsindependent single-cell cohort 5/5/5
- Participants
- 26 / 74 / 22
- Comparison
- Active GPA vs remission GPA vs healthy controls
- Active GPAn = 26
- Remission GPAn = 74
- Healthy controlsn = 22reference
- Outcome
- Circulating Tph (cTph) cell frequency, number and subset distribution
Methodological detailsage- and sex-matched healthy controls, flow cytometry, single-cell multi-omics profiling in an independent cohort
- Age- and sex-matched healthy controls
- Flow cytometry
- Single-cell multi-omics profiling in an independent cohort
Main finding
As reported in the abstract
cTph cells
- Active GPA: increased frequency and absolute number of cTph vs remission GPA
- Both GPA groups: cTph2-skewed distribution vs healthy controls
- Remission GPA with generalized disease: higher cTph frequencies than localized disease
- cTph from active GPA: activated phenotype, transcriptional profile with pro-inflammatory and survival-associated genes
- Plasma IL-21 did not differ significantly between the three groups
- Absolute counts of memory cTph and cTph2 correlated positively with clinical markers of disease activity and were significantly elevated with higher cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) titers
Original publication
Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis. Arthritis Res Ther. Published 6 December 2025. doi:10.
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