Circulating interleukin-6 and cardiovascular disease risk in patients with rheumatoid arthritis with low disease activity due to active therapy
Authors' conclusion
Although a direct association between IL-6 levels and traditional CV risk factors and subclinical carotid atherosclerosis was not observed, circulating IL-6 was associated with disease activity and acute-phase reactants, which have been associated with an increased risk of CV in these patients.
Study context
- Population
- Spanish patients with rheumatoid arthritis (RA)
- Participants
- 407 patients
- Outcome
- Relationship of serum IL-6 levels to subclinical carotid atherosclerosis and classic CV risk factors, incl. lipid profile and indices of insulin resistance and beta-cell function
Methodological detailsmultivariable analysis
- Multivariable analysis
Main finding
As reported in the abstract
Association of serum IL-6 levels with CV risk factors and subclinical carotid atherosclerosis
- Classic cardiovascular (CV) risk factors, lipid profile, insulin resistance indices and subclinical carotid atherosclerosis not associated with serum IL-6 levels
Observational data: associations, not effects.
Further findings
Association of IL-6 with RA features
- Circulating IL-6 correlated with acute phase reactants, disease activity and other features of RA
Original publication
Circulating interleukin-6 and cardiovascular disease risk in patients with rheumatoid arthritis with low disease activity due to active therapy. Clin Exp Rheumatol. Published 11 September 2022. doi:10.
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