Vasculitis & polymyalgia rheumatica
Circular RNA expression profiles and identification of hsa_circ_0028381 as a potential biomarker of anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors' conclusion
RNA-seq revealed that circRNAs are aberrantly expressed in the plasma of AAV patients. Hsa_circ_0028381 was implicated as a potential biomarker for AAV diagnosis and renal prognosis.
Study context
- Population
- AAV patients and healthy controls (HCs); discovery RNA-sequencing (RNA-seq) in 5 AAV patients and 5 HCsvalidation cohort
- Comparison
- AAV patients vs HCs and other connective tissue diseases (CTDs)
- AAVn = 51
- HCsn = 30reference
- Outcome
- Diagnostic value of plasma hsa_circ_0028381 for AAV (ROC analysis)
Methodological detailsRNA-sequencing discovery cohort, qRT-PCR validation cohort, ROC curve analysis
- RNA-sequencing discovery cohort
- qRT-PCR validation cohort
- ROC curve analysis
Performance
As reported in the abstract
Plasma hsa_circ_0028381 distinguishing AAV from controls (HCs and other CTDs)
| Test or model | AUC |
|---|---|
| AAV | 0.81 |
AAV
AUC0.81
Further findings
Aberrantly expressed circRNAs and mRNAs in AAV vs HCs (RNA-seq)
- circRNAs aberrantly expressed (62 upregulated, 81 downregulated)
- 143
- mRNAs aberrantly expressed (151 upregulated, 153 downregulated)
- 304
hsa_circ_0028381 and renal involvement / end-stage renal disease (ESRD)
- Associated with renal involvement
- Increased baseline levels predictive of progression to ESRD
Original publication
Circular RNA expression profiles and identification of hsa_circ_0028381 as a potential biomarker of anti-neutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Rheumatol. Published 26 April 2022. doi:10.
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