Chronic non-bacterial osteomyelitis in children- five-year standardized follow-up of a prospective observational cohort in the pre-biological era
Authors' conclusion
Most children experienced favourable long-term outcomes. Clinical improvement occurred more rapidly than radiologic resolution.
Study context
- Population
- Juvenile patients with chronic non-bacterial osteomyelitis, pre-biological era (study initiated 2002); naproxen first-line, escalation to SSZ, pamidronate and GC as needed
- Participants
- 37 patients
- Outcome
- Mean number of clinical lesions and MRI-detected lesions over follow-up
- Follow-up
- 12 and 60 months
Methodological detailslong-term, standardized 5-year follow-up, whole-body MRI
- Long-term
- Standardized 5-year follow-up
- Whole-body MRI
Main finding
As reported in the abstract
12 and 60 months
Mean number of clinical lesions, baseline to 12 months
2.1 to 0.4
Mean number of clinical lesions at 60 months
0.15
MRI-detected lesions, baseline to 12 months
5.0 to 2.25
MRI-detected lesions at 60 months
1.1
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Mean age at disease onset (years)
- 10.8
- Diagnostic delay (months)
- 5.8
Treatment escalation
- Second-line therapy initiated (patients)
- 10
- SSZ (n)
- 10
- Bisphosphonates (n)
- 1
- MTX (n)
- 1
- Short-term (< 4 wks) oral GC (n)
- 5
- Long-term oral GC (n)
- 3
- Second-line due to inadequate improvement in PGA, patient-reported overall wellbeing or MRI lesions
Original publication
Chronic non-bacterial osteomyelitis in children- five-year standardized follow-up of a prospective observational cohort in the pre-biological era. Pediatr Rheumatol Online J. Published 13 May 2025. doi:10.
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