Characterised intron retention profiles in muscle tissue of idiopathic inflammatory myopathy subtypes
Authors' conclusion
This study revealed distinct IRs and specific splicing factors associated with IIM subtypes, which might be contributing to the pathogenesis of IIM.
Study context
- Population
- Muscle tissues from patients with IIM and controls
- Participants
- 174 vs 19
- Comparison
- IIM subtypes vs controls
- IIMn = 174
- Controlsn = 19reference
- Outcome
- Changes in IR profiles in IIM subtypes, their influence on proteins and correlations with clinical features
Main finding
As reported in the abstract
IR profiles in IIM muscle
Intron retention (IRs) identified in all IIM subtypes vs controls
6783 IRs in 3111 unique genes
Original publication
Characterised intron retention profiles in muscle tissue of idiopathic inflammatory myopathy subtypes. Ann Rheum Dis. Published 12 June 2024. doi:10.
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