Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies
Authors' conclusion
This multiomics analysis elucidates distinct molecular mechanisms in IIM subtypes, identifying potential biomarkers for personalised prognosis and therapy.
Study context
- Population
- Han Chinese idiopathic inflammatory myopathies (IIM) cohort; muscle tissues from patients with IIM and controls203 IIM (44 validation) + 18 controls
- Comparison
- IIM subtypes vs controls
- Controlsn = 18reference
- Outcome
- Subtype-specific multiomics features and pathways (MOFA)
Methodological detailsmultiomics (RNA sequencing, proteomics, metabolomics), multiomics factor analysis (MOFA), independent validation cohort
- Multiomics (RNA sequencing, proteomics, metabolomics)
- MOFA
- Independent validation cohort
Main finding
As reported in the abstract
MOFA distinguished dermatomyositis (DM), immune-mediated necrotising myopathy (IMNM) and antisynthetase syndrome (ASyS) from controls; subtype-specific features and pathways identified (DM, IMNM, ASyS respectively), validated in an independent cohort
798, 748, and 297
DM: upregulated interferon (IFN) and cytokine pathways; IFN-related genes altered at exon, IR and protein levels, with changes in related metabolites
11
Original publication
Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies. Ann Rheum Dis. Published 11 September 2025. doi:10.
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