Spondyloarthritis & psoriatic arthritis
Characterisation of myeloid cells in circulation and synovial fluid of patients with psoriatic arthritis
Authors' conclusion
These preliminary findings support a potential role for surface antigens on PMNs and monocytes/macrophages as prognostic or disease activity monitoring tools.
Study context
- Population
- Patients with psoriatic arthritis (PsA); blood and synovial fluid (SF) leukocytes, incl. Polymorphonuclear neutrophils (PMNs) and monocyte/macrophages
- Comparison
- SF vs blood leukocytes in PsA; oral PMNs of non-arthritic controls
- Outcome
- Leukocyte activation state and correlation with disease activity
Methodological detailsmulticolour flow cytometry
- Multicolour flow cytometry
Main finding
As reported in the abstract
- SF PMNs showed elevated activation vs blood PMNs, but reduced vs oral PMNs of non-arthritic controls
- In vitro stimulation further activated SF PMNs (reserve capacity for activation)
- Significant variability between patients in SF PMN CD activation marker expression
- PMN CD marker expression consistent over two sequential visits in a subset of patients
- Disease activity markers increased with elevated SF macrophage numbers
- Several CD markers on blood or SF cells (e.g. PMN CD64) correlated with disease activity markers incl. pain score and DAPSA
Original publication
Characterisation of myeloid cells in circulation and synovial fluid of patients with psoriatic arthritis. RMD Open. Published 22 October 2024. doi:10.
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