Vasculitis & polymyalgia rheumatica
Characterisation of circulating endothelial microparticles in Behçet's disease: new markers of chronic endothelial damage?
Authors' conclusion
Levels of circulating EMPs are elevated in BD patients and correlate with the disease activity; the elevated EMPs may be a potential indicator to predict disease activity of BD.
Study context
- Population
- Consecutive patients with Behçet's disease (BD) and age- and sex-matched healthy controls
- Participants
- 39 vs 30
- Comparison
- BD patients vs age- and sex-matched healthy controls
- BDn = 39
- Healthy controlsn = 30reference
- Outcome
- Plasma levels of EMPs (CD31+ and CD42b-) measured by flow cytometry
Methodological detailsage- and sex-matched healthy controls, consecutive patients
- Age- and sex-matched healthy controls
- Consecutive patients
Main finding
As reported in the abstract
Circulating EMPs (CD31+ and CD42b-)
- BD vs Healthy controls: P = 0.000
Observational data: associations, not effects.
Further findings
Correlation of plasma EMPs with current BD activity
- Positive correlation, r
- 0.802
- P
- P = 0.000
Vascular and gastrointestinal involvement in BD by EMPs
- Vascular involvement significantly increased, P
- P = 0.004
- Gastrointestinal involvement significantly increased, P
- P = 0.011
Original publication
Characterisation of circulating endothelial microparticles in Behçet's disease: new markers of chronic endothelial damage? Clin Exp Rheumatol. Published 24 August 2022. doi:10.
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