Vasculitis & polymyalgia rheumatica

Extended ultrasound examination identifies more large vessel involvement in patients with giant cell arteritis

Rheumatology (Oxford)Published Diagnostic accuracy study

An erratum to this article was published (Rheumatology (Oxford), 1 Mar 2025 ↗)

Authors' conclusion

Extended A2-ultrasound examination identified more patients with LV involvement than the limited ultrasound method.

Study context

Population
Patients with newly diagnosed GCA, included at diagnosis
Participants
133 patients
Comparison
Extended A2-US vs limited US for detecting large vessel (LV) involvement
Outcome
Detection of LV involvement
Follow-up
At diagnosis
Methodological detailspaired comparison: all patients examined by both methods
  • Paired comparison: all patients examined by both methods

Performance

As reported in the abstract

LV involvement detected

P < 0.001

Further findings

Vertebral artery vasculitis as the only LVs involved

Patients
12 (9.0%)

GCA missed if only limited US performed

Patients
5 (3.8%)

GCA phenotype

Isolated cranial GCA
40 (30.0%)
Isolated large vessel GCA
21 (15.8%)
Mixed-GCA
72 (54.1%)

Original publication

Extended ultrasound examination identifies more large vessel involvement in patients with giant cell arteritis. Rheumatology (Oxford). Published 23 August 2022. doi:10.1093/rheumatology/keac478

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