CD44 is associated with muscle inflammation in polymyositis and skin damage in idiopathic inflammatory myopathy
Authors' conclusion
This study suggests that macrophages expressing CD44 may be involved in the pathogenesis of PM, and sCD44 could serve as a potential marker for skin damage and activity in IIM.
Study context
- Population
- Patients with idiopathic inflammatory myopathy (IIM) (polymyositis (PM), DM) and experimental autoimmune myositis (EAM) model mice
- Outcome
- CD44 expression and associations in PM and IIM
Methodological detailsbioinformatic analysis of GSE128470, GSE3112 and GSE39454 datasets, EAM mouse model, serum soluble CD44 (sCD44) by ELISA
- Bioinformatic analysis of GSE128470, GSE3112 and GSE39454 datasets
- EAM mouse model
- Serum sCD44 by ELISA
Main finding
As reported in the abstract
- CD44 correlation with M1 macrophages in PM
- r=0.57, p<0.0001
- CD44 correlation with M2 macrophages in PM
- r=0.57, p<0.0001
- CD44+F4/80+ macrophages in skeletal muscle increased in EAM mice; stronger association with M1 markers
- p<0.0001
- Serum sCD44 elevated in IIM
- p=0.0024
- Serum sCD44 elevated in PM
- p=0.0332
- Serum sCD44 elevated in DM
- p=0.0001
- Serum sCD44 elevated in anti-MDA5 antibody positive subtype
- p=0.0007
- sCD44 correlation with VAS in IIM
- r=0.4424, p=0.0013
- sCD44 correlation with myositis intention to treat activity index in IIM
- r=0.3938, p=0.0047
- sCD44 correlation with skin damage score in IIM
- r=0.3796, p=0.0101
- sCD44 correlation with skin activity score in IIM
- r=0.4625, p=0.0014
Original publication
CD44 is associated with muscle inflammation in polymyositis and skin damage in idiopathic inflammatory myopathy. Clin Exp Rheumatol. Published 22 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →