Cause‐Specific Mortality in Patients With Gout in the US Veterans Health Administration: A Matched Cohort Study
Authors' conclusion
A higher risk of death among gout patients in the VHA was related to comorbidity burden.
Study context
- Population
- US Veterans Health Administration patients with and without gout (mean age 67 years; 99% male), followed until death or December 2017matched cohort
- Exposure
- Gout vs matched patients without gout
- Outcome
- All-cause and cause-specific mortality (cause of death from the National Death Index)
Methodological detailsmatched up to 1:10 on birth year, sex and year of Veteran's Health Administration (VHA) enrollment, multivariable Cox regression
- Matched up to 1:10 on birth year, sex and year of VHA enrollment
- Multivariable Cox regression
Main finding
As reported in the abstract
All-cause mortality
Gout
246,291
events
Non-gout controls
2,000,000
events
Gout vs Non-gout controlsHazard ratio (95% CI)
After matching
1.09(1.08–1.09)
Adjusted for comorbidities
0.98(0.97–0.98)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Death from genitourinary conditions (strongest cause-specific association)Goutvs Non-gout controls | 1.50 (1.47–1.54) | |
| Death from neurologic conditions (e.g., Alzheimer's and Parkinson's disease)Goutvs Non-gout controls | 0.63 (0.62–0.65) | |
| Death from mental health conditionsGoutvs Non-gout controls | 0.66 (0.65–0.68) | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cause‐Specific Mortality in Patients With Gout in the US Veterans Health Administration: A Matched Cohort Study. Arthritis Care Res (Hoboken). Published 11 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →