Treat-to-target urate-lowering therapy and hospitalizations for gout: results from a nationwide cohort study in England
Authors' conclusion
ULT associates with an increased risk of hospitalizations within the first 6 months of initiation but reduces hospitalizations in the long term, particularly when serum urate targets are achieved.
Study context
- Population
- People with incident gout in England, 2004–2020incident gout
- Participants
- 292,270 people
- Exposure
- Urate-lowering therapy (ULT) initiation vs no ULT initiation; serum urate target attainment vs non-attainment; colchicine prophylaxis vs none
- Outcome
- Hospitalizations for gout
Methodological detailsnationwide, linked CPRD and NHS Digital HES data, Cox proportional hazards and propensity models
- Nationwide
- Linked CPRD and NHS Digital HES data
- Cox proportional hazards and propensity models
Main finding
As reported in the abstract
Hospitalizations for gout after ULT initiation
Adjusted hazard ratio (95% CI)P value
ULT initiationvs Did not initiate ULTwithin the first 6 months after ULT initiation
4.54(3.70–5.58)
P < 0.001ULT initiationvs Did not initiate ULTfrom 12 months after initiation
0.77(0.71–0.83)
P < 0.001Serum urate <360 micromol/l attainedvs Initiating ULT but not attaining this targetin ULT initiators, target attained within 12 months of initiation
0.57(0.49–0.67)
P < 0.001Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Treat-to-target urate-lowering therapy and hospitalizations for gout: results from a nationwide cohort study in England. Rheumatology (Oxford). Published 10 November 2022. doi:10.
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