Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis
Authors' conclusion
After MR analysis, although T1D may be a risk factor for bone health, we do not have sufficient evidence to support a causal effect of T1D on osteoporosis and fractures at a genetically predicted level.
Study context
- Population
- T1D instruments from a genome-wide association meta-analysis; fracture and osteoporosis data from the FinnGen Consortium
- Comparison
- Genetically predicted T1D and osteoporosis and fracture risk
- Outcome
- Osteoporosis (IVW primary analysis method)
Methodological detailsInverse-variance weighted (IVW) primary analysis, MR-Egger regression and weighted method (WME) sensitivity analyses, MR-PRESSO
- IVW primary analysis
- MR-Egger regression and WME sensitivity analyses
- MR-PRESSO
Main finding
As reported in the abstract
Osteoporosis
Estimate (95% CI)P value
T1D
OR (IVW) 1.040(0.974–1.109)
P = 0.238T1D
OR (MR-Egger) 1.077(0.921–1.260)
P = 0.372T1D
OR (WME) 1.021(0.935–1.114)
P = 0.643Further findings
Forearm fractures
| OR (IVW) (95% CI) | P value | ||
|---|---|---|---|
| T1DResults not robust enough | 1.062 (1.010–1.117) | P = 0.020 | |
| 0.512Odds ratio (IVW) (log scale) |
Femur, lumbar and pelvis, or shoulder and upper arm fractures
- No causal effect
Original publication
Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis. Osteoporos Int. Published 3 April 2023. doi:10.
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