Lupus & antiphospholipid syndrome
Catastrophic antiphospholipid syndrome: Clinical characteristics and outcomes in a non-caucasian population — A five-year experience from a single centre
Authors' conclusion
Our findings reveal a predominance of high-risk, secondary APS-mainly SLE-associated-with thrombocytopenia. Nearly half presented with CAPS as the initial APS manifestation. Limited access to full triple therapy significantly impacted mortality, which decreased from 100% with partial therapy to 21% with complete regimens.
Study context
- Population
- Patients fulfilling the CAPS classification criteria at a tertiary referral center in Mexico City, January 2019 to December 202374% female
- Participants
- 19 patients
- Outcome
- Clinical characteristics, treatment strategies, and outcomes of patients diagnosed with CAPS
Methodological detailssingle-centre, tertiary referral center
- Single-centre
- Tertiary referral center
Main finding
As reported in the abstract
Clinical characteristics, treatment and outcomes
- Primary antiphospholipid syndrome (APS)
- 6
- Concomitant systemic lupus erythematosus (SLE)
- 11
- Low-risk (2019 EULAR aPL titers classification)
- 7
- High-risk (2019 EULAR aPL titers classification)
- 12
- CAPS as first manifestation of APS
- 47%
- Precipitating factors identified (most commonly infections and anticoagulant withdrawal)
- 94.7%
- Arterial circulation affected
- 74%
- Venous circulation affected
- 68%
- Hematologic manifestations
- 47%
- Kidneys affected
- 42%
- Lungs affected
- 42%
- Heart affected
- 32%
- Anticoagulation
- 84%
- Corticosteroids
- 79%
- Plasma exchange
- 79%
- Triple therapy
- 74%
- Overall mortality
- 42%
- Full recovery with no relapses, among survivors
- 75%
Observational data: associations, not effects.
Original publication
Catastrophic antiphospholipid syndrome: Clinical characteristics and outcomes in a non-caucasian population — A five-year experience from a single centre. Lupus. Published 28 January 2026. doi:10.
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