Lupus & antiphospholipid syndrome
Malignancies in lupus nephritis: a retrospective cohort study on epidemiology and risk factors
Authors' conclusion
In patients with LN, the considerable risk of malignancy and its associated increase in mortality necessitate long-term monitoring, regardless of activity phase and disease duration.
Study context
- Population
- Patients diagnosed with lupus nephritis (LN) from 1969 to 2023median follow-up 15 years (IQR 6–25)
- Participants
- 290 patients
- Exposure
- Patients with malignancies vs patients without malignancies
- Outcome
- Epidemiology (prevalence, incidence) and predisposing factors for malignancy in LN
Methodological detailsunivariate logistic regression
- Univariate logistic regression
Main finding
As reported in the abstract
Malignancy · median follow-up 15 years
- Malignancies diagnosed
- 27
- Prevalence
- 9.3%
- Incidence per 1000 person-years
- 6.08
- Affecting the urinary tract
- 22.2%
- Affecting the skin
- 33.3%
- Occurred during a quiescent phase of LN
- 85.2%
Observational data: associations, not effects.
Further findings
Mortality
P = 0.012
Smokers
P = 0.001
Age at LN diagnosis
P = 0.035
Age at end of follow-up
P < 0.001
Cumulative GC dose
P = 0.031
Risk factors for malignancy (univariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| SmokingUnivariate analysis | 9.081 (1.921–42.937) | P < 0.001 | |
| Older ageUnivariate analysis | 1.058 (1.028–1.089) | P < 0.001 | |
| Higher proteinuria at LN onsetUnivariate analysis | 1.126 (1.024–1.237) | P = 0.016 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Malignancies in lupus nephritis: a retrospective cohort study on epidemiology and risk factors. Lupus Sci Med. Published 27 January 2026. doi:10.
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